Journal
STEM CELL RESEARCH
Volume 48, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2020.101981
Keywords
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Funding
- Slovak Research and Development Agency [APVV-17-0037]
- Ministry of Education, Science, Research and Sport of the Slovak Republic (VEGA) [1/0279/18]
- Operational Programme Research and Innovation - ERDF [ITMS: 26220120053]
- National Sustainability Program I [LO1609]
- [RVO: 67985904]
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We generated new in vitro model for sporadic form of amyotrophic lateral sclerosis by reprogramming isolated skin fibroblasts into iPSCs. Fibroblasts were reprogrammed with commercially available synthetic polycistronic, self-replicating RNA vector. As verified by FISH, an early passages of a new iPSC line showed mosaic karyotype (cells with normal and abnormal karyotype 46,XY,t(2;14)(q13;p12) were present), while late passages contained only cells with abnormal karyotype. New iPSCs differentiated into all three germ layers and formed a teratoma in nude mice. Our iPSC line represents a new model for therapy testing and drug development in the field of ALS research.
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