Journal
CURRENT ALLERGY AND ASTHMA REPORTS
Volume 16, Issue 8, Pages -Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-016-0634-5
Keywords
Cytolysis; Eosinophilic chronic rhinosinusitis; Eosinophils; ETosis; DNA traps; Neutrophils
Categories
Funding
- Research Grant on Allergic Disease and Immunology from Japan Agency for Medical Research and Development
- Charitable Trust Laboratory Medicine Research Foundation of Japan
- JSPS KAKENHI [16 K08926]
- Japanese Ministry of Health, Labor and Welfare [H27, H28-Research on measures for intractable disease-general-004]
- NIH [R37-AI020241, R01-AI051645, R01-HL095699]
- Grants-in-Aid for Scientific Research [15K08639, 15K10776] Funding Source: KAKEN
Ask authors/readers for more resources
The traditional paradigm of eosinophils as endstage damaging cells has mainly relied on their release of cytotoxic proteins. Cytokine-induced cell survival and secretion of granular contents from tissue-dwelling eosinophil are thought to be important mechanisms for eosinophilic inflammatory disorders, although the occurrence of cytolysis and its products (i.e., free extracellular granules) has been observed in affected lesions. Recent evidence indicates that activated eosinophils can exhibit a non-apoptotic cell death pathway, namely extracellular trap cell death (ETosis) that mediates the eosinophil cytolytic degranulation. Here, we discuss the current concept of eosinophil ETosis which provides a new look at eosinophilic inflammation. Lessons from eosinophilic chronic rhinosinusitis revealed that ETosis-derived DNA traps, composed of stable web-like chromatin, contribute to the properties of highly viscous eosinophilic mucin and impairments in its clearance. Intact granules entrapped in DNA traps are causing long-lasting inflammation but also might have immunoregulatory roles. Eosinophils possess a way to have post-postmortem impacts on innate immunity, local immune response, sterile inflammation, and tissue damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available