Journal
SOFT MATERIALS
Volume 19, Issue 4, Pages 373-381Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/1539445X.2020.1829642
Keywords
drug delivery; chitosan bead; iron oxide nanoparticle; bio-nanocomposite
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A novel dual-responsive supermagnetic chitosan/iron oxide nanocomposite hydrogel beads were prepared in this research, showing sensitivity to pH and external magnetic field for drug release. The results suggested that this hydrogel has significant potential for drug delivery applications.
In this research, a novel dual-responsive supermagnetic chitosan/iron oxide nanocomposite hydrogel beads (CH/MION) was prepared using sodium tripolyphosphate (STPP) as cross linking agent. The prepared CH/MION hydrogel was systematically characterized by Fourier transforminfrared spectroscopy (FT-IR), scanning electron microscopy (SEM) X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). In addition, the CH/MION hydrogel exhibits favorable swelling properties that are sensitive to pH, and external magnetic field (EMF). The drug release behavior of the prepared hydrogel under EMF, and different pHs was also studied. The obtained hydrogel showed considerable temperature, pH, and EMF sensitivity for the in vitro release of Doxorubicin (DOX).These results suggested that the CH/MION hydrogel beads could be a promising candidate for drug delivery applications.
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