Journal
SLEEP
Volume 44, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsaa166
Keywords
sleep duration; breast cancer; prospective; meta-analysis
Categories
Funding
- Cancer Research UK [C8821/A29017, C8221/A19170, C570/A16491]
- UK Medical Research Council [MR/K02700X/1, U137686853, MR/M012190/1]
- Nuffield Department of Population Health-Clarendon Fund-Brasenose College Kwai Cheong Scholarship
- MRC [MR/K02700X/1, G9900923, G0700474] Funding Source: UKRI
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The study found no significant association between sleep duration and breast cancer incidence. Both short and long duration of sleep did not show a significant influence on the risk of breast cancer.
Study objectives: To investigate the association between sleep duration and breast cancer incidence, we examined the association in a large UK prospective study and conducted a meta-analysis of prospective studies. Methods: In the Million Women Study, usual sleep duration over a 24-h period was collected in 2001 for 713,150 participants without prior cancer, heart problems, stroke, or diabetes (mean age = 60 years). Follow-up for breast cancer was by record linkage to national cancer registry data for 14.3 years on average from the 3-year resurvey. Cox regression models yielded multivariable-adjusted breast cancer relative risks (RR) and 95% confidence intervals (CIs) for sleep duration categories. Published prospective studies of sleep duration and breast cancer risk were included in a meta-analysis, which estimated the inverse-variance weighted average of study-specific log RRs for short and for long versus average duration sleep. Results: After excluding the first 5 years to minimize reverse causation bias in the Million Women Study, 24,476 women developed breast cancer. Compared with 7-8 h of sleep, the RRs for <6, 6, 9, and >9 h of sleep were 1.01 (95% CI, 0.95-1.07), 0.99 (0.96-1.03), 1.01 (0.96-1.06), and 1.03 (0.95-1.12), respectively. In a meta-analysis of 14 prospective studies plus the Million Women Study, including 65,410 breast cancer cases, neither short (RR < 7 h = 0.99 [0.98-1.01]) nor long (RR > 8 h = 1.01 [0.98-1.04]) versus average duration sleep was associated with breast cancer risk. Conclusions: The totality of the prospective evidence does not support an association between sleep duration and breast cancer risk.
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