Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 109, Issue -, Pages 76-85Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.08.008
Keywords
RIPK1; Ubiquitination
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Over the last two decades, research has focused on understanding the role of RIPK1 in cell survival and death pathways, particularly its involvement in NF-kappa B signaling and cell death processes. However, the specific impact of RIPK1 ubiquitination on signaling outcomes remains unclear due to the complexity of ubiquitin signaling.
Over the last two decades the mechanisms that underpin cell survival and cell death have been intensively studied. One molecule in particular, Receptor Interacting Protein Kinase 1 (RIPK1), has gained interest due to the ability to function upstream of both NF-kappa B signaling and caspase-dependent and -independent cell death. RIPK1 is critical in determining cell fate downstream of cytokine signaling receptors such as the Tumour Necrosis Factor Receptor Super Family (TNFRSF) and the innate immune Toll-like receptors. Various studies have attempted to untangle how ubiquitination of RIPK1 dictates signaling outcomes; however, due to the complex nature of ubiquitin signaling it has been difficult to prove that ubiquitination of RIPK1 does in fact influence signaling outcomes. Therefore, we ask the question: What do we really know about RIPK1 ubiquitination, and, to what extent can we conclude that ubiquitination of RIPK1 impacts RIPK1-mediated signaling events?
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