Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 114, Issue -, Pages 57-67Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.09.004
Keywords
RNA processing; Brain development; Neurological disorder; Therapy
Categories
Funding
- K01 NIAAA
- CDKL5 Program of Excellence Grant (Loulou Foundation)
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Gene expression involves a variety of enzymes, proteins, non-coding transcripts, and cellular structures, with RNA processing playing a crucial role in cell morphogenesis and neurological diseases in the brain.
Gene expression comprises a diverse array of enzymes, proteins, non-coding transcripts, and cellular structures to guide the transfer of genetic information to its various final products. In the brain, the coordination among genes, or lack thereof, characterizes individual brain regions, mediates a variety of brain-related disorders, and brings light to fundamental differences between species. RNA processing, occurring between transcription and translation, controls an essential portion of gene expression through splicing, editing, localization, stability, and interference. The machinery to regulate transcripts must operate with precision serving as a blueprint for proteins and non-coding RNAs to derive their identity. Therefore, RNA processing has a broad scope of influence in the brain, as it modulates cell morphogenesis during development and underlies mechanisms behind certain neurological diseases. Here, we present these ideas through recent findings on RNA processing in development and post-developmental maturity to advance therapeutic discoveries and the collective knowledge of the RNA life cycle.
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