Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 113, Issue -, Pages 57-64Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.08.009
Keywords
TopBP1; SLX4; MDC1; Homologous recombination; Mitosis; MiDAS; Anaphase Bridges
Categories
Funding
- Villum Foundation
- Danish National Research Foundation [DNRF115]
- Novo Nordisk Foundation
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TopBP1/Rad4/Dpb11 is a crucial eukaryotic protein involved in DNA replication, repair, checkpoint activation, and chromosome segregation. It acts as a scaffold to assemble protein complexes through phosphorylation-dependent interactions, and can adapt to scaffold different processes based on cell cycle regulated changes in phosphorylation of client proteins.
TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.
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