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TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
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MOLECULAR CELL (2009)
Involvement of linear polyubiquitylation of NEMO in NF-κB activation
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TNF-α induces two distinct caspase-8 activation pathways
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TRADD protein is an essential component of the RIG-like helicase antiviral pathway
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
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Identification of RIP1 kinase as a specific cellular target of necrostatins
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The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors
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NATURE IMMUNOLOGY (2008)
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
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Beyond tumor necrosis factor receptor:: TRADD signaling in toll-like receptors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
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CELLULAR SIGNALLING (2007)
Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis
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Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
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Ubiquitination of RIP is required for tumor necrosis factor α-induced NF-κB activation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
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MOLECULAR CELL (2006)
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
MORT1/FADD is involved in liver regeneration
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WORLD JOURNAL OF GASTROENTEROLOGY (2005)
Rip1 mediates the Trif-dependent Toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation
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