The effect of oxygen concentration on the coupled neurons: Rich spiking patterns and synchronization

The dynamical microenvironments play a crucial role in neuronal spiking patterns. In this paper, we investigated the effect of oxygen concentration on different synchronous spiking patterns of two coupled neuron models by including dynamical ion concentration. Two coupling modes of electrical diffusive coupling and potassium diffusive coupling were considered. In these two cases, oxygen concentration exhibited an important role in the synchronous spiking patterns between two coupled neurons, and extremely rich electrical activities were observed. For the potassium diffusive coupling, differential synchronous patterns of oscillation state (OS), synchronous epileptic seizure state (SSZ) and synchronous spreading depression state (SSD) as well as SZ and SD bursting states were generated. For the electrical diffusive coupling, differential synchronous patterns of resting state (RS), SSZ and SSD were observed.