Journal
SCIENCE CHINA-CHEMISTRY
Volume 64, Issue 1, Pages 61-65Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-020-9832-9
Keywords
1; 4-benzoxazepines; para-quinone methides; azaoxyallyl cations; cycloaddition; transition-metal-free
Categories
Funding
- National Natural Science Foundation of China [21971001, 21702001]
- Natural Science Foundation of Anhui Province [1808085MB47]
- Open Fund for Discipline Construction, Institute of Physical Science and Information Technology, Anhui University
- Anhui University
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A formal [4+3]-cycloaddition reaction between ortho-hydroxyphenyl-substituted para-quinone methides and in-situ generated azaoxyallyl cations is reported here. This reaction provides a very efficient route to a series of biologically important 1,4-benzoxazepine derivatives in good to excellent yields under mild reaction conditions.
A formal [4+3]-cycloaddition reaction ofortho-hydroxyphenyl-substituted para-quinone methides (p-QMs) within-situgenerated azaoxyallyl cations is reported. The reaction occurs under very mild reaction conditions (transition-metal free, room temperature, cheap inorganic base) and provides a very efficient route to a series of biologically important 1,4-benzoxazepine derivatives in good to excellent yields.
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