Journal
SCIENCE
Volume 370, Issue 6512, Pages 121-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abb6430
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Funding
- KAKENHI from the Japan Society for the Promotion of Science (JSPS) [19K22388, 18H02419, 17H06424, 17H06423, 20H05364, 19K16490]
- JSPS Research Fellowship for Young Scientists
- Grants-in-Aid for Scientific Research [20H05364, 19K22388, 19K16490, 17H06424, 17H06423, 18H02419] Funding Source: KAKEN
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The mammalian sex-determining gene Sry induces male development. Since its discovery 30 years ago, Sry has been believed to be a single-exon gene. Here, we identified a cryptic second exon of mouse Sry and a corresponding two-exon type Sry (Sry-T) transcript. XY mice lacking Sry-T were sex-reversed, and ectopic expression of Sry-T in XX mice induced male development. Sry-T messenger RNA is expressed similarly to that of canonical single-exon type Sry (Sry-S), but SRY-T protein is expressed predominantly because of the absence of a degron in the C terminus of SRY-S. Sry exon2 appears to have evolved recently in mice through acquisition of a retrotransposon-derived coding sequence to replace the degron. Our findings suggest that in nature, SRY-T, not SRY-S, is the bona fide testis-determining factor.
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