Journal
SCIENCE
Volume 370, Issue 6516, Pages 571-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abc0523
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Funding
- NIH [R35 GM11977401, R33-AI129455, K08-CA230156]
- University of Basel
- Charles and Helen Schwab Foundation
- Burroughs-Wellcome CAMS Award
- Gates Ventures, the private office of Bill Gates
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After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subsequently spread locally before active community surveillance was implemented.
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