Journal
SCIENCE
Volume 369, Issue 6504, Pages 663-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abb3377
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Funding
- Bill and Melinda Gates Foundation
- UK government's Department for International Development (DFID) through the Engineering Nitrogen Symbiosis for Africa project (ENSA) [OPP11772165]
- Danish National Research Foundation [DNRF79]
- Labex ARCANE
- Glyco@Alps [ANR-15-IDEX-02]
- PolyNat Carnot Institut [ANR-16-CARN-0025-01]
- CBH-EUR-GS [ANR-17-EURE-0003]
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Plants evolved lysine motif (LysM) receptors to recognize and parse microbial elicitors and drive intracellular signaling to limit or facilitate microbial colonization. We investigated how chitin and nodulation (Nod) factor receptors of Lotus japonicas initiate differential signaling of immunity or root nodule symbiosis. Two motifs in the LysM1 domains of these receptors determine specific recognition of ligands and discriminate between their in planta functions. These motifs define the ligand-binding site and make up the most structurally divergent regions in cognate Nod factor receptors. An adjacent motif modulates the specificity for Nod factor recognition and determines the selection of compatible rhizobial symbionts in legumes. We also identified how binding specificities in LysM receptors can be altered to facilitate Nod factor recognition and signaling from a chitin receptor, advancing the prospects of engineering rhizobial symbiosis into nonlegumes.
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