Journal
SCHIZOPHRENIA RESEARCH
Volume 224, Issue -, Pages 88-94Publisher
ELSEVIER
DOI: 10.1016/j.schres.2020.09.021
Keywords
Schizotypy; Grey matter volume; Structural covariance; Medial superior frontal gyrus
Categories
Funding
- National Key Research and Development Programme [2016YFC0906402]
- Beijing Municipal Science and Technology Commission [Z161100000216138]
- Beijing Training Project for the Leading Talents in S T [Z151100000315020]
- Chinese Academy of Science [XDB02030002]
- CAS Key Laboratory of Mental Health, Institute of Psychology
Ask authors/readers for more resources
In this study, we applied brain grey matter volume and structural covariance methods on T1 weighted images to delineate potential structural brain changes in individuals with high schizotypy, who were defined as healthy individuals scoring in the top tenth percentile of the Schizotypal Personality Questionnaire (SPQ). Eighty-seven college students with high schizotypy and 122 controls were recruited in China. Differences in grey matter volume and volume covariance between the two groups, and correlations of grey matter volume with SPQ scores in the high schizotypy group were examined. We found that individuals with high schizotypy had decreased grey matter volume at the left medial superior frontal gyrus (medsFG) extending towards the superior frontal gyrus, decreased structural covariance within the right medsFG, between the right superior frontal gyrus (sFG), the right superior temporal gyrus and the right anterior insula; and increased structural covariance between the caudate and the right inferior temporal gyrus. Correlation analysis revealed that grey matter volume of the left middle temporal pole and the right sFG correlated positively with the SPQ total scores, volume of the bilateral cerebellum 9 sub-region correlated negatively with the SPQ cognitive-perceptual sub-scale scores, volume of the bilateral striatum correlated positively with the SPQ interpersonal sub-scale scores, and volume of the bilateral superior temporal pole correlated positively with the SPQ disorganization sub-scale scores in the high schizotypy group. These results highlight important grey matter structural changes in the medsFG in individuals with high schizotypy. (C) 2020 Elsevier B.V. All rights reserved.y
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available