Journal
SCHIZOPHRENIA BULLETIN
Volume 46, Issue 6, Pages 1396-1408Publisher
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbaa117
Keywords
psychedelics; psychosis; hallucinations; seroto nin; Bayesian; computational
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Funding
- Wellcome Trust [WT108720]
- National Institute on Drug Abuse, USA [5R01 DA041336]
- Internal Grant Agency of the Ministry of Health of the Czech Republic [AZV 17-32957A]
- Heffter Research Institute, USA [2020-03-01]
- Durham University [609412]
- European Union [609412]
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The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.
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