Journal
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
Volume 50, Issue 2, Pages 118-123Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03009742.2020.1798500
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Funding
- Erasme Fund for Medical Research (Fonds Erasme pour la Recherche Medicale), Belgium
- charity fund CAP48 from RTBF Project 'Polyarthritis in children and young adults CAP48' (Polyarthrite de l'enfant et du jeune adulte CAP48) [B403201317717]
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The study found that anti-CarP antibodies were detected in a cohort of Belgian RA patients. In seronegative RA patients, the presence of anti-CarP antibodies was associated with higher disease activity and disability. Additionally, anti-CarP antibodies were also detected in primary SS patients and JIA patients.
Objectives: Anti-carbamylated protein antibodies (anti-CarP) are reported to be associated with increased disease activity and with more severe joint damage in rheumatoid arthritis (RA) patients. The present study investigated the presence of anti-CarP in various rheumatic diseases, and their specific clinical significance in RA, in Belgian rheumatology patients. Method: We tested sera from 254 RA patients, 56 healthy controls, and 153 patients with different rheumatic conditions: juvenile idiopathic arthritis (JIA), axial spondyloarthritis, systemic sclerosis, and Sjogren's syndrome (SS). An in-house enzyme-linked immunosorbent assay was used to detect immunoglobulin G antibodies against carbamylated foetal calf serum. Results: Anti-CarP were detected in 88 RA patients (34.6%), of whom 82% were also positive for anti-citrullinated protein antibodies (ACPAs) and 81% were also rheumatoid factor (RF) positive. Of note, 11 anti-CarP single-positive patients were detected (4.3%). The previously reported association with joint erosions was not detected. However, in ACPA- and RF-negative RA patients, the presence of anti-CarP was associated with higher disease activity and disability. Fifteen per cent of JIA patients and 30% of SS patients also tested positive for anti-CarP and their antibody levels did not differ significantly from those of anti-CarP-positive RA patients. Anti-CarP levels were, however, significantly higher in ACPA- or RF-positive patients. Conclusion: Anti-CarP antibodies were detected in the sera of a cohort of Belgian RA patients. Moreover, they were also detected in primary SS patients and in JIA patients. In the seronegative subset of RA patients, anti-CarP antibodies showed prognostic value.
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