Journal
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Volume 93, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/sji.12977
Keywords
COVID-19; cytokine storm syndrome; liver diseases; liver transplantation; SARS-CoV-2
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Liver injury in patients with COVID-19 is frequent but mild, possibly directly caused by virus-induced cytopathic effects. The relationship between SARS-CoV-2 infection, acute response, and liver involvement requires further exploration based on updated literature data.
In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
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