Gut microbiota on gender bias in autism spectrum disorder

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Its three core symptoms are social communication disorder, communication disorder, narrow interest and stereotyped repetitive behavior. The proportion of male and female autistic patients is 4:1. Many researchers have studied this phenomenon, but the mechanism is still unclear. This review mainly discusses the related mechanism from the perspective of gut microbiota and introduces the influence of gut microbiota on the difference of ASD between men and women, as well as how gut microbiota may affect the gender dimorphism of ASD through metabolite of microbiota, immunity, and genetics, which provide some useful information for those who are interested in this research and find more gender-specific treatment for autistic men and women.

Automated summary

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by symptoms such as social communication disorder, communication disorder, narrow interests, and stereotyped repetitive behavior. The ratio of male to female patients with autism is 4:1, and gut microbiota may influence the differences between men and women with ASD.