Journal
RADIATION ONCOLOGY
Volume 15, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13014-020-01654-9
Keywords
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Funding
- Munich Excellence Training Initiative for Physician Scientists (Metiphys)
- CPC-M translational funds (German Center for Lung Research (DZL))
- German Cancer Consortium (DKTK)
- DFG [GRK 2338]
- BMBF [02NUK047C]
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
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Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.
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