Related references
Note: Only part of the references are listed.Fumarate hydratase in cancer: A multifaceted tumour suppressor
Christina Schmidt et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)
Impact of hypoxia on DNA repair and genome integrity
Alanna R. Kaplan et al.
MUTAGENESIS (2020)
Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
Ling F. Ye et al.
ACS CHEMICAL BIOLOGY (2020)
PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
Rimma Belotserkovskaya et al.
NATURE COMMUNICATIONS (2020)
Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
Debora Grasso et al.
FRONTIERS IN PHARMACOLOGY (2020)
Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
Klaudia Szymonowicz et al.
CELLS (2020)
Oncometabolites suppress DNA repair by disrupting local chromatin signalling
Parker L. Sulkowski et al.
NATURE (2020)
Histone methylation and the DNA damage response
Fade Gong et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)
Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E inhibition in melanoma
B. Shannan et al.
EUROPEAN JOURNAL OF CANCER (2019)
NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance
Francesco Marampon et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)
Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy
Erika Zernickel et al.
MOLECULAR CANCER THERAPEUTICS (2019)
State-of-the-art strategies for targeting the DNA damage response in cancer
Patrick G. Pilie et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
Targeting ARID1A-mutant colorectal cancer: depletion of ARID1B increases radiosensitivity and modulates DNA damage response
B. Niedermaier et al.
SCIENTIFIC REPORTS (2019)
The Future of Radiobiology
David G. Kirsch et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome
Ahmed Salem et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
Sevin Turcan et al.
NATURE GENETICS (2018)
Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome
Ahmed Salem et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
The Future of Radiobiology
David G. Kirsch et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)
Succinate induces hepatic fibrogenesis by promoting activation, proliferation, and migration, and inhibiting apoptosis of hepatic stellate cells
So Young Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Role of metabolism in cancer cell radioresistance and radiosensitization methods
Le Tang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
Parker L. Sulkowski et al.
NATURE GENETICS (2018)
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Lukas Bunse et al.
NATURE MEDICINE (2018)
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
Alan Ashworth et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
Epigenetic modifiers: activities in renal cell carcinoma
Aguirre A. de Cubas et al.
NATURE REVIEWS UROLOGY (2018)
Wild-type and mutated IDH1/2 enzymes and therapy responses
Remco J. Molenaar et al.
ONCOGENE (2018)
Exosomes in cancer: Use them or target them?
Nuno Bastos et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)
Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect
Po-Lin Tseng et al.
SCIENTIFIC REPORTS (2018)
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
Theo A. Knijnenburg et al.
CELL REPORTS (2018)
Histone methylation in DNA repair and clinical practice: new findings during the past 5-years
Shuhua Wei et al.
JOURNAL OF CANCER (2018)
The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
Julian Hlouschek et al.
FRONTIERS IN ONCOLOGY (2018)
THE EVOLUTION OF RADIATION THERAPY IN TREATING CANCER
Dorothy Abshire et al.
SEMINARS IN ONCOLOGY NURSING (2018)
Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
Julian Hlouschek et al.
CANCER LETTERS (2018)
Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells
Anja Weber et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation
Timothy I. Johnson et al.
CELL DEATH & DISEASE (2018)
Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor
Kuang-Tai Kuo et al.
CLINICAL EPIGENETICS (2018)
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
Juan Bayo et al.
CELL REPORTS (2018)
Radiation effects on antitumor immune responses: current perspectives and challenges
Thomas Walle et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)
Regulation of DNA Repair Mechanisms: How the Chromatin Environment Regulates the DNA Damage Response
Jens Stadler et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
Isabelle R. Miousse et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2017)
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
Xin Liu et al.
NATURE CELL BIOLOGY (2017)
The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Elena Anso et al.
NATURE CELL BIOLOGY (2017)
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
Andrew M. Intlekofer et al.
NATURE CHEMICAL BIOLOGY (2017)
PARP inhibitors: Synthetic lethality in the clinic
Christopher J. Lord et al.
SCIENCE (2017)
Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling
Laurence M. Gagne et al.
TRENDS IN CELL BIOLOGY (2017)
Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation
Xianmin Mu et al.
ONCOTARGET (2017)
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Petros A. Tyrakis et al.
CELL REPORTS (2017)
Mitochondrial respiratory gene expression is suppressed in many cancers
Ed Reznik et al.
ELIFE (2017)
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
Ryota Nakashima et al.
SCIENTIFIC REPORTS (2017)
Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission
So Hee Ko et al.
SCIENTIFIC REPORTS (2017)
Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance
Elie Hatem et al.
ANTIOXIDANTS & REDOX SIGNALING (2017)
Metabolic synthetic lethality in cancer therapy
Vincent Zecchini et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)
Oncometabolites D- and L-2-Hydroxyglutarate Inhibit the AIkB Family DNA Repair Enzymes under Physiological Conditions
Fangyi Chen et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2017)
Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate
Ovidiu C. Andronesi et al.
CLINICAL CANCER RESEARCH (2016)
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
Tuomas Laukka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
Johann Matschke et al.
ANTIOXIDANTS & REDOX SIGNALING (2016)
Oncometabolites: Unconventional triggers of oncogenic signalling cascades
Marco Sciacovelli et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Role of TET enzymes in DNA methylation, development, and cancer
Kasper Dindler Rasmussen et al.
GENES & DEVELOPMENT (2016)
When Genome Maintenance Goes Badly Awry
Elizabeth M. Kass et al.
MOLECULAR CELL (2016)
Epigenome Maintenance in Response to DNA Damage
Juliette Dabin et al.
MOLECULAR CELL (2016)
Jumonji histone demethylases as emerging therapeutic targets
Sung Yeon Park et al.
PHARMACOLOGICAL RESEARCH (2016)
Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
Johann Matschke et al.
RADIATION ONCOLOGY (2016)
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
Edoardo Gaude et al.
NATURE COMMUNICATIONS (2016)
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
Rajesha Rupaimoole et al.
CANCER DISCOVERY (2016)
Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents
Mauro Corrado et al.
ONCOTARGET (2016)
Oncometabolic Nuclear Reprogramming of Cancer Stemness
Javier A. Menendez et al.
STEM CELL REPORTS (2016)
Metabolic control of cancer cell stemness: Lessons from iPS cells
Javier A. Menendez
CELL CYCLE (2015)
Hypoxia Induces Production of L-2-Hydroxyglutarate
Andrew M. Intlekofer et al.
CELL METABOLISM (2015)
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
Xudong Fu et al.
CELL METABOLISM (2015)
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
William M. Oldham et al.
CELL METABOLISM (2015)
Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells
Andrew J. Worth et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2015)
Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment
Susan E. Scanlon et al.
DNA REPAIR (2015)
Lung Cancer Cell Line Screen Links Fanconi Anemia/BRCA Pathway Defects to Increased Relative Biological Effectiveness of Proton Radiation
Qi Liu et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2015)
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Yuhui Jiang et al.
NATURE CELL BIOLOGY (2015)
Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation
Andrea O. Fontana et al.
RADIOTHERAPY AND ONCOLOGY (2015)
Deciphering the molecular basis of invasiveness in Sdhb-deficient cells
Celine Loriot et al.
ONCOTARGET (2015)
Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents
Pu Wang et al.
CELL REPORTS (2015)
Protein-mediated assembly of succinate dehydrogenase and its cofactors
Jonathan G. Van Vranken et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
Holly E. Barker et al.
NATURE REVIEWS CANCER (2015)
Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer
Carole Sourbier et al.
CANCER CELL (2014)
Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation
Nicole Grosse et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2014)
Applying Synthetic Lethality for the Selective Targeting of Cancer
Donal P. McLornan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Epigenetics in radiotherapy: Where are we heading?
Kim M. Smits et al.
RADIOTHERAPY AND ONCOLOGY (2014)
SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker
Vamsi K. Kolukula et al.
ONCOTARGET (2014)
Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
Andrew R. Mullen et al.
CELL REPORTS (2014)
Optogenetic control of ROS production
Andrew P. Wojtovich et al.
REDOX BIOLOGY (2014)
Defects in mitochondrial metabolism and cancer
Edoardo Gaude et al.
CANCER & METABOLISM (2014)
Deficiency in SLC25A1, Encoding the Mitochondrial Citrate Carrier, Causes Combined D-2-and L-2-Hydroxyglutaric Aciduria
Benjamin Nota et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Influence of Metabolism on Epigenetics and Disease
William G. Kaelin et al.
CELL (2013)
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
Julie-Aurore Losman et al.
GENES & DEVELOPMENT (2013)
Kdm4b Histone Demethylase Is a DNA Damage Response Protein and Confers a Survival Advantage following γ-Irradiation
Leah C. Young et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Oncometabolites: linking altered metabolism with cancer
Ming Yang et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. M. Tannahill et al.
NATURE (2013)
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice
Agnes Schipler et al.
NUCLEIC ACIDS RESEARCH (2013)
Correction: Travelling Waves of a Delayed SIR Epidemic Model with Nonlinear Incidence Rate and Spatial Diffusion
Jing Yang et al.
PLoS One (2013)
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS
Kasper M. Rouschop et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor
J. Keith Killian et al.
CANCER DISCOVERY (2013)
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy
Emil Mladenov et al.
FRONTIERS IN ONCOLOGY (2013)
The evolution of the cancer niche during multistage carcinogenesis
Mary Helen Barcellos-Hoff et al.
NATURE REVIEWS CANCER (2013)
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Patrick S. Ward et al.
CANCER CELL (2012)
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Mengtao Xiao et al.
GENES & DEVELOPMENT (2012)
Repair of DNA damage induced by accelerated heavy ionsuA mini review
Ryuichi Okayasu
INTERNATIONAL JOURNAL OF CANCER (2012)
How cancer metabolism is tuned for proliferation and vulnerable to disruption
Almut Schulze et al.
NATURE (2012)
Metabolomics of urinary organic acids in respiratory chain deficiencies in children
Carolus J. Reinecke et al.
METABOLOMICS (2012)
Possible Role of Exosomes Containing RNA in Mediating Nontargeted Effect of Ionizing Radiation
Ammar H. J. Al-Mayah et al.
RADIATION RESEARCH (2012)
Alterations of metabolic genes and metabolites in cancer
Eric K. Oermann et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
The emerging role of fumarate as an oncometabolite
Ming Yang et al.
FRONTIERS IN ONCOLOGY (2012)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
M-P Puissegur et al.
CELL DEATH AND DIFFERENTIATION (2011)
Inborn and acquired metabolic defects in cancer
Christian Frezza et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2011)
Succinate independently stimulates full platelet activation via cAMP and phosphoinositide 3-kinase-β signaling
C. Hogberg et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways
Emil Mladenov et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)
Epigenetic changes of DNA repair genes in cancer
Christoph Lahtz et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2011)
miR-378☆ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway
Lillian J. Eichner et al.
CELL METABOLISM (2010)
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks
Tomohiro Hayakawa et al.
JOURNAL OF CELL SCIENCE (2010)
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
Johanna Chiche et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Global analysis of CpG methylation reveals epigenetic control of the radiosensitivity in lung cancer cell lines
E-H Kim et al.
ONCOGENE (2010)
Platelet-Derived Growth Factor C Is Upregulated in Human Uterine Fibroids and Regulates Uterine Smooth Muscle Cell Growth
Guangli Suo et al.
BIOLOGY OF REPRODUCTION (2009)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
NATURE (2009)
Metabolic Enzymes as Oncogenes or Tumor Suppressors
Craig B. Thompson
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
Norman Chan et al.
CANCER RESEARCH (2008)
Hypoxia, DNA repair and genetic instability
Robert G. Bristow et al.
NATURE REVIEWS CANCER (2008)
Molecular biology for the radiation oncologist: the 5Rs of radiobiology meet the hallmarks of cancer
K. Harrington et al.
CLINICAL ONCOLOGY (2007)
Succinate dehydrogenase and fumarate hydratase:: linking mitochondrial dysfunction and cancer
A. King et al.
ONCOGENE (2006)
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
JS Isaacs et al.
CANCER CELL (2005)
Hallmarks of 'BRCAness' in sporadic cancers
N Turner et al.
NATURE REVIEWS CANCER (2004)
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
WH He et al.
NATURE (2004)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)