Journal
PROTEIN SCIENCE
Volume 30, Issue 1, Pages 115-124Publisher
WILEY
DOI: 10.1002/pro.3959
Keywords
coronavirus; COVID-19; ligand assessment; PDB; reproducibility; SARS-CoV-2; structure validation; structure-guided drug discovery
Categories
Funding
- Austrian Science Fund [P32821]
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
- Narodowe Centrum Nauki [2020/01/0/NZ1/00134]
- National Institute of General Medical Sciences [R01-GM132595]
- Polish National Agency for Academic Exchange [PPN/BEK/2018/00058/U/00001]
- Austrian Science Fund (FWF) [P32821] Funding Source: Austrian Science Fund (FWF)
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The COVID-19 pandemic has sparked scientific activities to understand the SARS-CoV-2 virus and develop treatments. Structural biologists have identified hundreds of experimental structures related to this coronavirus, and a new online resource, covid19.bioreproducibility.org, provides expert-verified information about these models for biomedical researchers.
The COVID-19 pandemic has triggered numerous scientific activities aimed at understanding the SARS-CoV-2 virus and ultimately developing treatments. Structural biologists have already determined hundreds of experimental X-ray, cryo-EM, and NMR structures of proteins and nucleic acids related to this coronavirus, and this number is still growing. To help biomedical researchers, who may not necessarily be experts in structural biology, navigate through the flood of structural models, we have created an online resource,covid19.bioreproducibility.org, that aggregates expert-verified information about SARS-CoV-2-related macromolecular models. In this article, we describe this web resource along with the suite of tools and methodologies used for assessing the structures presented therein.
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