Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 43, Pages 27004-27015Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2010361117
Keywords
striatum; calcium imaging; probabilistic classical conditioning; value; reward
Categories
Funding
- Research Center Program of the Institute for Basic Science [IBS-R002-A1]
- National Research Foundation [NRF-2019R1A2C4069863]
- National Research Foundation (NRF-2016-Fostering Core Leaders of the Future Basic Science Program/Global PhD Fellowship Program)
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To obtain insights into striatel neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatel neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatel neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, value-related spatial clusters were progressively refined during classical conditioning. Our study shows the broad and learning-dependent spatial organization of functional clusters of dorsal striatel neurons in the direct and indirect pathways. These findings further argue against the classic model of the basal ganglia and support the importance of spatiotemporal patterns of striatel neuronal ensemble activity in the control of behavior.
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