Journal
POLYMER TESTING
Volume 93, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2020.106914
Keywords
PVA/ZnO electrospun Nanofibers; Antibacterial; Cytotoxicity; Wound healing; Histological analysis
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PVA nanofibers incorporated with ZnO nanoparticles were successfully fabricated and characterized by various analysis techniques, demonstrating good dispersion and antibacterial properties of the nanoparticles. In vivo experiments further proved the accelerated wound healing properties of PVA/ZnO composite nanofibers.
Poly vinyl alcohol (PVA) nanofibers incorporated with ZnO nanoparticles were successfully fabricated by electrospinning technique. The developed nanofibrous composites were characterized by structural and morphological analysis techniques including X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FESEM). Good dispersion of the nanoparticles in the resultant nanofibers was observed and the incorporated nanoparticles of ZnO were in the shape of flower buds. Moreover, porosity and swelling properties of the prepared membranes were evaluated. Antibacterial, cytotoxicity assays as well as in-vivo wound healing experiments in mice were also studied. The minimum inhibitory concentration (MIC) of PVA/ZnO nanoparticles against S. aureus and E. coli was 250 and 62.5 mu g/mL respectively, indicating the antibacterial activities of the nanocomposite fibers relating to the zinc oxide nanoparticles. In-vivo studies and higher values of transforming growth factor-beta (TGF-beta) further proved that PVA/ZnO composite nanofibers had accelerated wound healing properties. ZnO nanoparticles were responsible for the accelerated epithelial regeneration and better cell attachment based on the histological analysis.
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