Journal
PLOS ONE
Volume 15, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0228525
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Funding
- Ministry of Higher Education and Science of Russia [RFMEFI60417X0181, 14.604.21.0181, FSMG-2020-0003, 07500337-20-03]
- RFBR [20-34-70132]
- Russian Science Foundation [20-16-00088]
- Russian Science Foundation [20-16-00088] Funding Source: Russian Science Foundation
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The toxic effect of strained hydrocarbon 2,2'-bis (bicyclo[2.2.1]heptane) (BBH) was studied using whole-cell bacterial lux-biosensors based onEscherichia colicells in which luciferase genes are transcriptionally fused with stress-inducible promoters. It was shown that BBH has the genotoxic effect causing bacterial SOS response however no alkylating effect has been revealed. In addition to DNA damage, there is an oxidative effect causing the response of OxyR/S and SoxR/S regulons. The most sensitive to BBH lux-biosensor wasE.colipSoxS-lux which reacts to the appearance of superoxide anion radicals in the cell. It is assumed that the oxidation of BBH leads to the generation of reactive oxygen species, which provide the main contribution to the genotoxicity of this substance.
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