Journal
PHYTOTHERAPY RESEARCH
Volume 35, Issue 5, Pages 2274-2286Publisher
WILEY
DOI: 10.1002/ptr.6875
Keywords
artepillin C; green propolis; pharmacological properties; phenolic compounds
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2017/04138-8]
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Propolis is a viscous resin produced by bees, consisting of various bioactive substances with its chemical composition depending on factors such as plant sources and geographic origin. Baccharis dracunculifolia is an important botanical source of propolis, with one of its main bioactive constituents being Artepillin C. Artepillin C has multiple pharmacological effects, including gastroprotective, anti-inflammatory, antimicrobial, antioxidant, and antitumor properties.
Propolis is a viscous resin consisting of plant material (shoots, flowers, and plant exudates), salivary secretions and waxes produced byApis melliferabees. Its popular use aroused the interests of scientific research, which proved to be a potential source of various bioactive substances. The chemical composition of propolis depends on several factors, such as the different types of plant sources collected by bees, geographic origin, and the time of year in which they are produced, but it is known that phenolic represent the main bioactive constituents of propolis.Baccharis dracunculifoliaDC (Asteraceae) is the most important botanical source of propolis and a native to southeastern Brazil. It is widely known as the green propolis because of its deep green color. One of its major phenolic acids is artepillin C (Art-C), a diprenyl-p-hydroxycinnamic acid derivative. This review aims to provide a comprehensive summary of the pharmacological effects of Art-C. The limited number of publications on this topic over the past two decades have been collected from databases and summarized. Numerous biological activities have been described for the Art-C, such as gastroprotective, anti-inflammatory, antimicrobial, antioxidant, antitumor. This article describes aspects of occurrence, synthesis, biological activities and pharmacokinetic approaches.
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