Journal
PHYTOCHEMISTRY
Volume 178, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112462
Keywords
Avicennia marina (Forssk.) vierh.; Cladosporium oxysporum; Mangrove endophytic fungus; Macrolide; Thiocladospolide
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Funding
- Major national science and technology projects of the Ministry of science and technology [81991522]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- National Natural Science Foundation of China [41976105]
- Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) [2018SDKJ0401-2]
- Taishan Scholar Youth Expert Program in Shandong Province [Tsqn201812021]
- Fundamental Research Funds for the Central Universities [201941001]
- Youth Innovation Plan of Shandong province [2019KJM004]
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Five undescribed 12-membered macrolides containing thioethers, thiocladospolides F-J, together with the known biogenetic related analogues, were isolated from a mangrove-derived endophytic fungus Cladosporium oxysporum. The absolute configuration of thiocladospolide F was deduced by single-crystal X-ray diffraction, and those of thiocladospolides G-J were determined based on specific optical rotation and electronic circular dichroism (ECD) data, as well as the biogenetic considerations. Thiocladospolide G display the best antimicrobial activity against the aquatic pathogen Edwardsiella tarda with minimal inhibit concentration (MIC) value of 4 mu g/mL.
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