Journal
PHYTOCHEMISTRY
Volume 177, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112448
Keywords
Schisandra incarnata Stapf; Schisandraceae; Triterpenoids; Immunosuppressive activity
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Funding
- National Natural Science Foundation of China [31770380, 21572073, 31270394]
- Fundamental Research Funds for the Central Universities [2016YXMS150]
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Six undescribed triterpenoids, schincarins A-F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B-D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo K alpha irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 mu M, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 mu M, respectively.
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