Journal
PHYSIOLOGY
Volume 35, Issue 5, Pages 288-301Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00019.2020
Keywords
coagulation; COVID-19; cytokine storm; multisystem organ failure; pathophysiolog
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Funding
- Foundation Grant from the Canadian Institutes of Health Research (CIHR) [353989]
- Restracomp Scholarship (Hospital for Sick Children)
- Ontario Graduate Scholarship (OGS)
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The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death.
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