Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 375, Issue 1809, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2019.0559
Keywords
MMP; embryogenesis; cranial placodes; neural crest; Xenopus
Categories
Funding
- National Institutes of Health [R01-DE25806]
- NYU CSCB by NIH [1P30DE020754]
- Fondation pour la Recherche Medicale [FRMAJE201224]
- Midi-Pyrenees regional council [13053025]
- CNRS
Ask authors/readers for more resources
Matrix metalloproteinases (MMPs) are a large family of proteases comprising 24 members in vertebrates. They are well known for their extracellular matrix remodelling activity. MMP28 is the latest member of the family to be discovered. It is a secreted MMP involved in wound healing, immune system maturation, cell survival and migration. MMP28 is also expressed during embryogenesis in human and mouse. Here, we describe the detailed expression profile of MMP28 in Xenopus laevis embryos. We show that MMP28 is expressed maternally and accumulates at neurula and tail bud stages specifically in the cranial placode territories adjacent to migrating neural crest cells. As a secreted MMP, MMP28 may be required in neural crest-placode interactions. This article is part of a discussion meeting issue 'Contemporary morphogenesis'.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available