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Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function
Dyan Sellayah et al.
CELL METABOLISM (2011)
Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas
Rayner Rodriguez-Diaz et al.
CELL METABOLISM (2011)
Cigarette Smoking, Nicotine, and Body Weight
J. Audrain-McGovern et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Neuropsychiatric Adverse Effects of Centrally Acting Antiobesity Drugs
Pradeep J. Nathan et al.
CNS NEUROSCIENCE & THERAPEUTICS (2011)
Activation of the Cholinergic Antiinflammatory Pathway Ameliorates Obesity-Induced Inflammation and Insulin Resistance
XianFeng Wang et al.
ENDOCRINOLOGY (2011)
Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences
Hao Huang et al.
JOURNAL OF NEUROPHYSIOLOGY (2011)
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
Rayner Rodriguez-Diaz et al.
NATURE MEDICINE (2011)
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids
Mahesh M. Karnani et al.
NEURON (2011)
Reward Mechanisms in Obesity: New Insights and Future Directions
Paul J. Kenny
NEURON (2011)
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
Ki Woo Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants
Donna Meng et al.
PSYCHOPHARMACOLOGY (2011)
Nicotine Decreases Food Intake Through Activation of POMC Neurons
Yann S. Mineur et al.
SCIENCE (2011)
Treatment of nicotine addiction: present therapeutic options and pipeline developments
Riccardo Polosa et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2011)
Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action
F. Thomas Wunderlich et al.
CELL METABOLISM (2010)
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
Miguel Lopez et al.
FRONTIERS IN NEUROENDOCRINOLOGY (2010)
Hypocretins Regulate the Anxiogenic-Like Effects of Nicotine and Induce Reinstatement of Nicotine-Seeking Behavior
Ainhoa Plaza-Zabala et al.
JOURNAL OF NEUROSCIENCE (2010)
An alpha 7 Nicotinic Acetylcholine Receptor-Selective Agonist Reduces Weight Gain and Metabolic Changes in a Mouse Model of Diabetes
Mario B. Marrero et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
High Fat Diet Altered the Mechanism of Energy Homeostasis Induced by Nicotine and Withdrawal in C57BL/6 Mice
Young-Na Hur et al.
MOLECULES AND CELLS (2010)
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
Miguel Lopez et al.
NATURE MEDICINE (2010)
Cellular bioenergetics as a target for obesity therapy
Yu-Hua Tseng et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Transplantation of adipose tissue and stem cells: role in metabolism and disease
Thien T. Tran et al.
NATURE REVIEWS ENDOCRINOLOGY (2010)
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
Jean-Pierre Changeux
NATURE REVIEWS NEUROSCIENCE (2010)
Neurobiological mechanisms involved in nicotine dependence and reward: Participation of the endogenous opioid system
Fernando Berrendero et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2010)
Brown fat as a therapy for obesity and diabetes
Aaron M. Cypess et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2010)
Participation of corticotropin-releasing factor type 2 receptors in the acute, chronic and withdrawal actions of nicotine associated with feeding behavior in rats
Sandesh P. Kamdi et al.
APPETITE (2009)
Structural and functional diversity of native brain neuronal nicotinic receptors
Cecilia Gotti et al.
BIOCHEMICAL PHARMACOLOGY (2009)
kappa-Opioid receptor signaling and brain reward function
Adrie W. Bruijnzeel
BRAIN RESEARCH REVIEWS (2009)
Enhanced orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
Hiromasa Funato et al.
CELL METABOLISM (2009)
A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats
Chun-Xia Yi et al.
DIABETES (2009)
Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking
Bryan C. Bergman et al.
DIABETES (2009)
Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice
Masahiko Ito et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
Maria Cristina Zingaretti et al.
FASEB JOURNAL (2009)
Simultaneous Silencing of Npy and Dbh Expression in Hindbrain A1/C1 Catecholamine Cells Suppresses Glucoprivic Feeding
Ai-Jun Li et al.
JOURNAL OF NEUROSCIENCE (2009)
Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity
Ruben Nogueiras et al.
JOURNAL OF NEUROSCIENCE (2009)
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Antoine Taly et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
The influence of mecamylamine on ethanol and sucrose self-administration
Matthew M. Ford et al.
NEUROPHARMACOLOGY (2009)
Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor
Asuka Mano-Otagiri et al.
NEUROSCIENCE LETTERS (2009)
A role for Melanin-Concentrating Hormone in learning and memory
Antoine Adamantidis et al.
PEPTIDES (2009)
Consequences of smoking for body weight, body fat distribution, and insulin resistance
Arnaud Chiolero et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2008)
Activation of orexin/hypocretin projections to basal forebrain and paraventricular thalamus by acute nicotine
Ravi K. Pasumarthi et al.
BRAIN RESEARCH BULLETIN (2008)
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
Miguel Lopez et al.
CELL METABOLISM (2008)
Global burden of obesity in 2005 and projections to 2030
T. Kelly et al.
INTERNATIONAL JOURNAL OF OBESITY (2008)
Cholinergic regulation of orexin/hypocretin neurons through M3 muscarinic receptor in mice
Kousaku Ohno et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)
CART peptides: regulators of body weight, reward and other functions
G. Rogge et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Insular hypocretin transmission regulates nicotine reward
Jonathan A. Hollander et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation
P. Scholze et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Robin Christensen et al.
LANCET (2007)
Heterogeneity and complexity of native brain nicotinic receptors
Cecilia Gotti et al.
BIOCHEMICAL PHARMACOLOGY (2007)
A-366833:: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist:: Synthesis, analgesic efficacy and tolerability profile in animal models
Jianguo Ji et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
Lydia E. Kuo et al.
NATURE MEDICINE (2007)
Clinical and neurobiological aspects of narcolepsy
Seiji Nishino
SLEEP MEDICINE (2007)
Silencing of estrogen receptor a in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
Sergei Musatov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Nicotine administration effects on feeding and cocaine-amphetamine-regulated transcript (CART) expression in the hypothalamus
Phillip R. Kramer et al.
REGULATORY PEPTIDES (2007)
Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice
Alice Fornari et al.
NEUROSCIENCE LETTERS (2007)
Effects of high dose transdermal nicotine replacement in cigarette smokers
Dorothy Hatsukami et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2007)
Differentiation in the short- and long-term effects, of smoking on plasma total ghrelin concentrations between mare nonsmokers and habitual smokers
Alexander Kokkinos et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2007)
Stereological estimates of the basal forebrain cell population in the rat, including neurons containing choline acetyltransferase, glutamic acid decarboxylase or phosphate-activated glutaminase and colocalizing vesicular glutamate transporters
I. Gritti et al.
NEUROSCIENCE (2006)
Innervation of orexin/hlypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins
Pablo Henny et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2006)
Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors
Karla B. Mihalak et al.
MOLECULAR PHARMACOLOGY (2006)
Cigarette smoking saturates brain α4β2 nicotinic acetylcholine receptors
Arthur L. Brody et al.
ARCHIVES OF GENERAL PSYCHIATRY (2006)
Differential responsiveness of dopamine-β-hydroxylase gene expression to glucoprivation in different catecholamine cell groups
Ai-Jun Li et al.
ENDOCRINOLOGY (2006)
A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
Dinesh Gautam et al.
CELL METABOLISM (2006)
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
W Zhang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2006)
Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study
TK Houston et al.
BMJ-BRITISH MEDICAL JOURNAL (2006)
Thermogenic mechanisms and their hormonal regulation
JE Silva
PHYSIOLOGICAL REVIEWS (2006)
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
H Inoue et al.
CELL METABOLISM (2006)
Activation of orexin neurons by acute nicotine
RK Pasumarthi et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Orexin A in the VTA is critical for the induction of synaptic plasticity and Behavioral Sensitization to cocaine
SL Borgland et al.
NEURON (2006)
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
O Cabrera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Afferents to the orexin neurons of the rat brain
K Yoshida et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2006)
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
H Dhillon et al.
NEURON (2006)
Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
T Alon et al.
JOURNAL OF NEUROSCIENCE (2006)
Brain neuronal nicotinic receptors as new targets for drug discovery
C Gotti et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Cecilia Gotti et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice
YH Jo et al.
JOURNAL OF NEUROSCIENCE (2005)
A role for lateral hypothalamic orexin neurons in reward seeking
GC Harris et al.
NATURE (2005)
Lower core body temperature and attenuated nicotine-induced hypothermic response in mice lacking the β4 neuronal nicotinic acetylcholine receptor subunit
R Sack et al.
BRAIN RESEARCH BULLETIN (2005)
Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice
S Mashiko et al.
ENDOCRINOLOGY (2005)
Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms
E Kokkotou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2005)
Desensitization of nicotinic ACh receptors: shaping cholinergic signaling
R Giniatullin et al.
TRENDS IN NEUROSCIENCES (2005)
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions
J Hara et al.
NEUROSCIENCE LETTERS (2005)
Dual regulatory effects of orexins on sympathetic nerve activity innervating brown adipose tissue in rats
T Yasuda et al.
ENDOCRINOLOGY (2005)
Anatomy and regulation of the central melanocortin system
RD Cone
NATURE NEUROSCIENCE (2005)
Input of orexin/hypocretin by a genetically encoded neurons revealed tracer in mice
T Sakurai et al.
NEURON (2005)
Rapid upregulation of α7 nicotinic acetylcholine receptors by tyrosine dephosphorylation
CH Cho et al.
JOURNAL OF NEUROSCIENCE (2005)
Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice
H Chen et al.
NEUROPSYCHOPHARMACOLOGY (2005)
The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus Accumbens to modulate feeding Behavior and forced-swim performance
D Georgescu et al.
JOURNAL OF NEUROSCIENCE (2005)
Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
D Burdakov et al.
JOURNAL OF NEUROSCIENCE (2005)
Meal patterns in female rats during and after intermittent nicotine administration
LL Bellinger et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2005)
Metabolism and disposition kinetics of nicotine
J Hukkanen et al.
PHARMACOLOGICAL REVIEWS (2005)
Evidence for functional nicotinic receptors on pancreatic β cells
H Yoshikawa et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2005)
Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices
L Bayer et al.
NEUROSCIENCE (2005)
The pharmacological actions of nicotine on the gastrointestinal tract
WKK Wu et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2004)
The effect of smoking on peripheral insulin sensitivity and plasma endothelin level
AM Borissova et al.
DIABETES & METABOLISM (2004)
Glucoprivation increases expression of neuropeptide Y mRNA in hindbrain neurons that innervate the hypothalamus
AJ Li et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus
GQ Chang et al.
ENDOCRINOLOGY (2004)
Nicotine amplifies reward-related dopamine signals in striatum
ME Rice et al.
NATURE NEUROSCIENCE (2004)
Brown adipose tissue: Function and physiological significance
B Cannon et al.
PHYSIOLOGICAL REVIEWS (2004)
Acute effects of nicotine on serum glucose, insulin, growth hormone, and cortisol in healthy smokers
TM Morgan et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2004)
Smoking, fat mass and activation of the tumor necrosis factor-α pathway
JM Fernandez-Real et al.
INTERNATIONAL JOURNAL OF OBESITY (2003)
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype
G Segal-Lieberman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats
LP Shearman et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Hypothalamic orexin neurons regulate arousal according to energy balance in mice
A Yamanaka et al.
NEURON (2003)
Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats
MH Jang et al.
BRAIN RESEARCH (2003)
Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
LM Seoane et al.
ENDOCRINOLOGY (2003)
Long-term oral nicotine administration reduces insulin resistance in obese rats
RH Liu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Nicotinic receptor-mediated effects on appetite and food intake
YH Jo et al.
JOURNAL OF NEUROBIOLOGY (2002)
Cholinergic modulation of purinergic and GABAergic co-transmission at in vitro hypothalamic synapses
YH Jo et al.
JOURNAL OF NEUROPHYSIOLOGY (2002)
Nicotine and its withdrawal alter feeding induced by paraventricular hypothalamic injections of neuropeptide Y in Sprague-Dawley rats
C Bishop et al.
PSYCHOPHARMACOLOGY (2002)
Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections
R Ferrari et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism
DJ Marsh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nicotine reduces the incidence of type I diabetes in mice
JG Mabley et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus
M Lopez et al.
NEUROENDOCRINOLOGY (2002)
Orexin (hypocretin) neurons contain dynorphin
TC Chou et al.
JOURNAL OF NEUROSCIENCE (2001)
Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic receptors
K Andersson et al.
INTERNATIONAL JOURNAL OF OBESITY (2001)
Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain
Y Saito et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2001)
Cigarette smoking and diabetes mellitus: evidence of a positive association from a large prospective cohort study
JC Will et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2001)
Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats
K Arai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2001)
Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects
T Axelsson et al.
JOURNAL OF INTERNAL MEDICINE (2001)
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
MA Cowley et al.
NATURE (2001)
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
J Hara et al.
NEURON (2001)
The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia
B Ahrén et al.
DIABETES (2001)
Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation
N Fujiki et al.
NEUROREPORT (2001)
Fos expression in orexin neurons varies with behavioral state
IV Estabrooke et al.
JOURNAL OF NEUROSCIENCE (2001)
Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
DS Ludwig et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat
JK Kane et al.
NEUROSCIENCE LETTERS (2001)
Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats
R Liu et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2001)
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
AC Haynes et al.
REGULATORY PEPTIDES (2000)
Ghrelin induces adiposity in rodents
M Tschöp et al.
NATURE (2000)
Nicotine administration enhances NPY expression in the rat hypothalamus
MD Li et al.
BRAIN RESEARCH (2000)
Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus
M López et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Effects of abstinence from cigarette smoking on the cardiorespiratory capacity
K Hashizume et al.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2000)