Journal
PHARMACOLOGICAL REPORTS
Volume 72, Issue 5, Pages 1218-1226Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s43440-020-00143-w
Keywords
Free radicals; Oxygen species; Nitrogen species; Oxidative stress; Epileptogenesis
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Funding
- Medical University of Lublin [DS 475/20, DS 473/20]
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In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of redox messengers. In a state of oxidative stress, they trigger a cascade of events leading to epileptogenesis. During this latent, free of seizures period, a cascade of neurological changes takes place and finally leads to spontaneous recurrent seizures. The main processes involved in seizure generation are: neuroinflammation, neurodegeneration with anomalous neuroregeneration and lowering seizure threshold. Time of epileptogenesis offers a unique therapeutic window to prevent or at least attenuate seizure development. Animal data indicate that some antioxidants (for instance, resveratrol) may bear an anti-epileptogenic potential.
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