Journal
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume 171, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2020.104733
Keywords
Pyridaben; Insecticides; Trophectoderm; Endometrial cells; Pregnancy
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [2018R1C1B6009048, 2019R1A2C2089914]
- National Research Foundation of Korea [2019R1A2C2089914] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The detrimental effects of pesticides on pregnancy, specifically pyridaben, have been studied in pig reproductive cell lines, showing harmful impacts on early pregnancy through inhibition of cell signal transduction and induction of reactive oxygen species production, mitochondrial dysfunction, and apoptosis. Autophagy induced by pyridaben may also affect placentation, suggesting potential similar effects in human pregnancy.
Recently, infertility has become a major global issue. It is crucial to identify environmental factors that lead to infertility. The prevalent use of pesticides in agriculture results in the exposure of livestock and humans to these pesticides. Studies have reported the harmful effects of pesticides on pregnancy. Pyridaben, a pesticide that inhibits mitochondrial complex 1, has been reported to have detrimental effects on neurons, spermatogenesis, hormonal balance, and embryonic development. However, the effect of pyridaben on the female reproductive system has not yet been studied. Therefore, in this study, we evaluated the effects of pyridaben on early pregnancy in porcine reproductive cell lines, which are known to mimic the female reproductive system. Results demonstrated that pyridaben decreased cell growth in porcine endometrial luminal epithelial and porcine trophectoderm cell lines through inhibition of cell signal transduction. Further, pyridaben increased subG1 phase and late apoptosis through the induction of reactive oxygen species production, mitochondrial dysfunction, calcium unbalances, pro-apoptotic signals, and endoplasmic reticulum (ER) stress. Moreover, we found that pyridaben induced autophagy and inhibition of placentation through the regulation of ER-mitochondria axis proteins. Overall, pyridaben was found to be harmful in early pregnancy in pigs and may have similar effects in human pregnancy.
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