Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 40, Issue 2, Pages 109-115Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000002933
Keywords
brain abscess; Streptococcus milleri group; Staphylococcus aureus; bacterial meningitis; congenital heart disease
Categories
Funding
- nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019XK320080]
- Pediatric Medical Coordinated Development Center of Beijing Municipal Administration [XTZD20180501]
- Beijing Hospital Authority Dengfeng Talent Training Plan [DFL 20181201]
Ask authors/readers for more resources
Pediatric brain abscess is a serious disease with high mortality in children. Patients with multiple abscesses and intraventricular rupture of brain abscess/hydrocephalus have a higher risk of unfavorable outcomes.
Background: There are limit studies about pediatric brain abscess in China. The aim of this study was to analyze clinical characteristics and outcomes of pediatric brain abscess in recent years in China. Methods: The clinical information of children with brain abscess hospitalized in Beijing Children's Hospital between January 1, 2007 and December 31, 2016 were retrospectively reviewed. Results: Ninety-four children were enrolled in this study. A Streptococcus milleri group (13.8%) was identified as the most common causative organisms, followed by Staphylococcus aureus (6.4%). The overall mortality was 21.6%, with 50.0% of deaths happening in the first week after diagnosis. Longterm outcomes of 74 patients were assessed with Glasgow Outcome Scale-Extended Pediatric Reversion: 50 patients with a score of 1-2 (favorable outcome) and 24 patients with a score of 3-8 (unfavorable outcome). Patients with multiple abscesses (P = 0.029) and intraventricular rupture of brain abscess/hydrocephalus (P = 0.024) had higher risk of unfavorable outcomes. Conclusions: Brain abscess is a serious disease with high mortality in children; more aggressive treatments should be considered in the first week of diagnosis because of high risk of death, and for patients with multiple brain abscesses and intraventricular rupture of brain abscess/hydrocephalus because of their higher risk of unfavorable.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available