Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 40, Issue 1, Pages E43-E45Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000002936
Keywords
infant; tuberculosis; prevention; isoniazid; adherence; urine
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Funding
- Thrasher Research Fund
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Center for Advancing Translational Sciences at National Institutes of Health (NIH) [NIH/NIAID K23AI120793, NIH UL1TR000423]
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In an infant tuberculosis prevention trial in Kenya, urine isoniazid metabolite-detecting dipsticks were used to assess adherence. Positive test results were associated with maternal secondary education, HIV suppression, and no reported missed doses in the past 3 days, suggesting caregiver education and self-medication influenced infant adherence.
We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed: 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.
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