Wilms tumor

The objectives for the treatment of Wilms tumor in both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) have focused on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Although the timing of surgery is different in COG (upfront surgery) and SIOP (upfront chemotherapy with delayed surgery), both are effective strategies and have the same survival. Fewer patients are treated with radiotherapy in the SIOP trials but with higher doses. The prognostic significance of biological markers such as 1q gain and clinical outcomes with novel radiation techniques such as intensity modulated radiation therapy will be determined in upcoming clinical trials. A closer collaboration between COG and SIOP could help promote research and improve the clinical outcomes of children with Wilms tumor.

Automated summary

The objectives of the treatment of Wilms tumor by COG and SIOP focus on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Different strategies are employed by COG and SIOP, but both achieve the same survival rates. Future research will explore the prognostic significance of biological markers and the impact of radiation techniques on clinical outcomes. Collaboration between COG and SIOP may further research and enhance clinical outcomes for children with Wilms tumor.