Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 24, Issue 9, Pages 1725-1734Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00348
Keywords
classical chiral resolution; synthetic intermediate; Z-score statistical analysis; resolving agent; crystallization solvent
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Using a statistical Z-score methodology, enantiomeric excess (ee) data from our historical high-throughput classical chiral resolution screens were analyzed. In total, 19 of the screens used chiral acids as resolving agents, and 20 used chiral bases. The results show clear trends in terms of the selection of chiral acids/bases in conjunction with a crystallization solvent. We rank ordered resolving agents, solvents, and resolving agent/solvent combinations by applying the Z-score method on the ee of isolated solids, and provided recommendations on executing more efficient classical chiral resolution screening for synthetic intermediates.
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