Journal
ORGANIC LETTERS
Volume 22, Issue 20, Pages 7991-7996Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02920
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Funding
- National Natural Science Foundation of China [21625201, 21961142010, 21661140001, 91853202, 21521003]
- National Key Research and Development Program of China [2017YFA0505200]
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910001001]
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We report herein the diversity-oriented synthesis of various tetracyclic Isodon diterpenoid scaffolds guided by radical cyclization logic. Our substrate-based dienyne radical cyclization approach is distinctive from reagent-based rearrangement approaches that are generally applied in biosynthesis or previous synthetic studies. An unprecedented cyclization at C-14 via 1,5-radical translocation/5-exo-trig cyclization is observed, which enriches our radical cyclization pattern. Furthermore, biological evaluations revealed that several new natural product-like compounds showed promising anticancer activities against various cancer cell lines.
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