Journal
ORGANIC LETTERS
Volume 22, Issue 17, Pages 6907-6910Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02440
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Funding
- JSPS KAKENHI [17K05781]
- Grants-in-Aid for Scientific Research [17K05781] Funding Source: KAKEN
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1-Methyl-1H-tetrazol-5-yl (MT) alkyl sulfones 1b, 3b, and 7b react with various unsymmetrical ketones in the presence of LiHMDS in THF at low temperature to give trisubstituted (Z)-alkenes in good yields stereoselectively (Z/E = 91:9 to 99:1). For sterically less demanding ketones, olefination using t-Bu reagents 1d and 3d generated (Z)-alkenes with higher stereoselectivity (93:7-99:1).
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