Journal
ORGANIC LETTERS
Volume 22, Issue 17, Pages 7030-7033Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02578
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Funding
- EPFL (Switzerland)
- Swiss National Science Foundation (SNSF) [20020-155973]
- CONACYT (Mexico) [CVU 256937, 554166/290817]
- DAIP-UG
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In the presence of a catalytic amount of Pd(OAc)(2) and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regioselective oxypalladation and reductive elimination. One carbon-oxygen and two carbon-carbon bonds are generated to afford the heterocycle in good to excellent yield.
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