Journal
ORGANIC LETTERS
Volume 22, Issue 17, Pages 6948-6953Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02505
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Funding
- National Natural Science Foundation of China [21871260, 21502192]
- Chinese Academy of Sciences [XDB20000000]
- Fujian Natural Science Foundation [2018J05035]
- China Postdoctoral Science Foundation [2018M630734]
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We report the highly regio- and enantioselective alkynylation of alkynyl 1,2-diketones under Lewis acid catalysis, leading to the formation of a series of biologically important 3(2H)-furanones with high to excellent ee values. Moreover, a slight change of the reaction conditions produces a range of highly functionalized alpha-hydroxy ketones with a high level of enantioselectivity. A variety of further transformations can be easily achieved, demonstrating the synthetic potential of this protocol.
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