4.8 Article

Imidazole-Selective Alkyne Hydroamination under Physiological Conditions

Journal

ORGANIC LETTERS
Volume 22, Issue 19, Pages 7588-7593

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02785

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Funding

  1. National Research Foundation of Korea [2014R1A5A1011165]

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Imidazole-selective intermolecular hydroamination reaction has been discovered. This unprecedented additive-free addition reaction proceeds in an exclusively regioselective and stereoselective manner with high atom economy under extremely mild reaction conditions.

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