Journal
ORGANIC LETTERS
Volume 22, Issue 19, Pages 7522-7525Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02709
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Funding
- National Natural Science Foundation of China [81773604]
- Liaoning Natural Science Foundation [20170540856]
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Two nonbiaryl axially chiral beta-carboline-quinazoline dimers, pegaharmols A (1) and B (2), were isolated from the roots of Peganum harmala. Their planar structures were elucidated by the spectroscopic methods of high-resolution mass spectrometry and 1D and 2D nuclear magnetic resonance (NMR). The stereochemistry was established by a comparison between the experimental data of NMR and electronic circular dichroism and the computed data by quantum mechanical calculations. It is discovered for the first time that the beta-carboline at the C-8 position is bonded to the vasicine at the C-9 position. 1 exhibited moderate cytotoxic activity against HL-60 and A549 cell lines.
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