Journal
ORGANIC LETTERS
Volume 22, Issue 18, Pages 7310-7314Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02650
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Funding
- National Key R&D Program of China [2017YFC1703800]
- National Natural Science Foundation of China [81973190, 81803376]
- Guangdong Basic and Applied Basic Research Foundation [2020B1515020033]
- Natural Science Foundation of Guangdong Province [2018B030311020]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y036]
- high performance public computing service platform of Jinan University
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Pegaharines A-G (1-6), six novel beta-carboline alkaloids representing three types of skeleton, were isolated from the seeds of Peganum harmala. Compound 1 is a peculiar beta-carboline alkaloid characterized by the unprecedented carbon skeleton of an azepine-indole system. Compounds 3-6 represent the first examples of heterodimers constructed from rare tetracyclic beta-carboline and classic tricyclic beta-carboline alkaloids. Compounds 1 and 2 were characterized by X-ray crystallography. Compound 4 exhibited strong antiviral activity against HSV-2, with an IC50 value of 2.12 +/- 0.14 mu M.
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