Journal
ORGANIC LETTERS
Volume 22, Issue 18, Pages 7094-7097Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02400
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Funding
- National Natural Science Foundation of China [21871053, 21532001]
- Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]
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A straightforward and stereoselective preparation of (Z)-beta-alkenyl sulfones through a reaction of N-tosyl acrylamides, 1,4-diazabicyclo[2.2.2]octane-sulfur dioxide, and aryldiazonium tetrafluoroborates under copper catalysis is accomplished. The direct C(sp(2))-H arylsulfonylation of acrylamides using sulfur dioxide as the sulfonyl source in the presence of copper trifluoroacetate proceeds smoothly, giving rise to (Z)-beta-alkenyl sulfones in good yields. During the reaction process, excellent regio- and stereoselectivities are observed.
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