Journal
ORGANIC LETTERS
Volume 22, Issue 21, Pages 8278-8284Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02921
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21602126, 91753111, 21675103, 21804081]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
- Higher Educational Science and Technology Program of Shandong Province [J18KA077]
Ask authors/readers for more resources
A nickel-catalyzed enantioselective transfer hydrogenation and deuteration of N-sulfonyl imines was developed. Excellent a-selectivity and high deuterium content were achieved by using inexpensive 2-propanol-d(8) as a deuterium source. As a highlight, no deuteration of beta-C-H and the remote C-H of N-sulfonyl amines occurred, which is hard to achieve using other imines or by hydrogen isotope exchange with D2O. Mechanism studies indicated a stepwise pathway through the [Ni-D] intermediate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available