Journal
ORGANIC LETTERS
Volume 22, Issue 21, Pages 8528-8532Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03130
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21971080, 21971079, 21772051]
- Fundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU18QN011]
- Educational Commission of Hubei Province [D20192503]
- 111 Project [B17019]
Ask authors/readers for more resources
A novel and efficient multicomponent cyclization of methyl ketones, cyanamides, and arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation of four C-N bonds is reported. This multicomponent reaction is characterized by the employment of two molecules of cyanamide for double C(sp(3))-H amination of methyl ketones, avoiding complicated prepreparation of substrates and expanding the substrate scope. Furthermore, this multicomponent cyclization strategy provides a new approach for generating diverse 2,4-diamino-1,3,5-triazines with a broad substrate scope under mild conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available