Journal
OPTICS LETTERS
Volume 45, Issue 19, Pages 5401-5404Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.401643
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Funding
- Research Grants Council, University Grants Committee [26203619]
- Hong Kong University of Science and Technology [R9421]
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Ultraviolet photoacoustic microscopy (UV-PAM) has recently been demonstrated as a potential imaging tool for surgical margin analysis (SMA). UV-PAM does not require staining or micrometer-thick slicing, which is inevitable in conventional histological imaging. To promote UV-PAM as a practical intraoperative diagnostic tool, the imaging speed should be improved while preserving the high-resolution imaging capability and simplistic system design. In this Letter, we developed a galvanometer mirror-based UV-PAM (GM-UV-PAM) system for high-speed histology-like imaging. By using a UV laser with a high repetition rate (55 kHz) and a one-dimensional galvanometer mirror, our GM-UV-PAM system can generate subcellular images in less than 15 min for a typical brain biopsy (5 mm x 5 mm), with a lateral resolution of similar to 1.0 mu m. The images of mouse brain slices obtained by our GM-UV-PAM system show that it can provide histological information for SMA. (C) 2020 Optical Society of America
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