Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 97, Issue -, Pages 56-64Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2015.08.003
Keywords
Hyperthermia; Radiation therapy; IMRT; Heat therapy
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Hyperthermia has long been used for cancer treatment, either alone or in combination with chemotherapy, radiation therapy, or both. Its efficacy and versatility continue to be well demonstrated in randomized trials across a number of primary cancers, but barriers to its widespread adoption persist including effective delivery and verification systems. This article describes hyperthermia, details its biological mechanisms of action and immunological effects, and summarizes select preclinical data and key clinical trials combining hyperthermia with standard cancer treatments. Current challenges and emerging technologies that have the potential to make this translational therapy more accessible to a greater number of patients are also described. Published by Elsevier Ireland Ltd.
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