Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 97, Issue -, Pages 152-156Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2015.08.008
Keywords
Ovarian cancer; Heat shock protein; Diagnosis; Drug target; Chemoresistance
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Ovarian cancer (OC) is a major problem in gynecological oncology. Options for diagnosis and treatment of advanced stages and thus for patient prognosis have not been improved substantially over the past decades. Heat shock proteins (HSP) are characterized as stress-induced molecular chaperones performing cell survival factor functions. In cancer cells, various crucial and clinically important cell responses are vitally influenced and modulated by HSPs, e.g., cell growth and treatment resistance. Despite the limited knowledge on HSPs in OC progression, their roles as biomarkers, prognostic factors and their drug target properties appears promising for future clinical applications and therapeutic approaches. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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