Journal
ONCOLOGY REPORTS
Volume 44, Issue 6, Pages 2345-2352Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2020.7800
Keywords
hepatocellular carcinoma; intrahepatic metastasis; coagulation-fibrinolytic system; anti-anoikis; immune escape
Categories
Funding
- National Natural Science Foundation of China [81670594, 81470791, 81376597]
- Basic Research Innovation Group Program of Gansu Province [1606RJIA328]
- Scientific Research of Health Services Program of Gansu Province [GSWSKY2017-09]
- Talent Staff Fund of the Second Hospital of Lanzhou University [ynyjrckyzx2015-1-01]
- Talents Innovation and Entrepreneurship Program of Lanzhou City [2017-RC-62]
- Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital [CY2017-ZD01]
- Fundamental Research Funds for the Central Universities [lzujbky-2017-79]
- Key Project of Science and Technology in Gansu Province [19ZD2WA001]
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Hepatocellular carcinoma (HCC) is different from other solid tumors because it is commonly associated with the occurrence of intrahepatic metastasis. Additionally, the liver, unlike other organs, is the main site of coagulation and fibrinolytic factor production. Therefore, it was speculated that coagulation and fibrinolytic factors could be associated with intrahepatic metastasis of HCC. Do the coagulation and fibrinolytic systems protect HCC cells against anoikis during infiltration and metastasis? Conversely, do the coagulation and fibrinolytic systems lead to immune escape of HCC cells by affecting the immune microenvironment of patients? The current review aimed to present a number of novel hypotheses for the treatment of HCC by exploring the mechanisms of coagulation and fibrinolytic factors in the regulation of cancer growth.
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